Charged amino acids may promote coronavirus SARS-CoV-2 fusion with the host cell

نویسندگان

چکیده

The charged amino acids in the spike protein of SARS-CoV-2 exhibit some specific distribution. In RBD region S1 unit positive charge dominates interior and negative prevails on surface exposed towards ACE2 receptor. S2 preceding heptad repeats SARS-CoV-2, a central concentration, imbalance charge. idea that both distributions may, an electrostatic manner, facilitate coronavirus infection cell is presented. An evaluation virus-receptor binding energy, by docking peptide resembling human receptor site to virus RBD, estimation electromechanical deformation membrane during prefusion process were included. Possible prevention viral suggested.

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ژورنال

عنوان ژورنال: AIMS biophysics

سال: 2021

ISSN: ['2377-9098']

DOI: https://doi.org/10.3934/biophy.2021008